Research Paper Volume 13, Issue 17 pp 21102—21121

Bortezomib enhances the anti-cancer effect of the novel Bruton’s tyrosine kinase inhibitor (BGB-3111) in mantle cell lymphoma expressing BTK

Low-dose BTZ enhances the inhibitory effect mediated by the low-dose BGB-3111 in the MCL cells. (A) Cell viability in the Jeko-1, Rec-1, and Z138 treated with varying doses of BTZ for 24 or 48 h. (B) Cell viability in the Jeko-1, Rec-1, and Z138 treated with single or combination of low-dose BGB-3111 and BTZ for 48 h. (C) The combination index of cell proliferation in the Jeko-1, Rec-1, and Z138 treated with low-dose BGB-3111 combined with low-dose BTZ. Results are the mean ± SD of three independent experiments.

Figure 6. Low-dose BTZ enhances the inhibitory effect mediated by the low-dose BGB-3111 in the MCL cells. (A) Cell viability in the Jeko-1, Rec-1, and Z138 treated with varying doses of BTZ for 24 or 48 h. (B) Cell viability in the Jeko-1, Rec-1, and Z138 treated with single or combination of low-dose BGB-3111 and BTZ for 48 h. (C) The combination index of cell proliferation in the Jeko-1, Rec-1, and Z138 treated with low-dose BGB-3111 combined with low-dose BTZ. Results are the mean ± SD of three independent experiments.