Research Paper Volume 13, Issue 14 pp 18701—18717

Development and validation of a novel epigenetic-related prognostic signature and candidate drugs for patients with lung adenocarcinoma

Differentially expressed epigenetic-related genes (ERGs) in lung adenocarcinoma (LUAD). (A) A flow diagram of the study. (B) Heatmap of ERGs between LUAD and nontumor tissues in TCGA database. The color from green to orange represents the progression from low expression to high expression. (C) Volcano plot of ERGs in TCGA database. The orange dots in the plot represents upregulated genes and green dots represents downregulated genes with statistical significance. Gray dots represent no differentially expressed genes.

Figure 1. Differentially expressed epigenetic-related genes (ERGs) in lung adenocarcinoma (LUAD). (A) A flow diagram of the study. (B) Heatmap of ERGs between LUAD and nontumor tissues in TCGA database. The color from green to orange represents the progression from low expression to high expression. (C) Volcano plot of ERGs in TCGA database. The orange dots in the plot represents upregulated genes and green dots represents downregulated genes with statistical significance. Gray dots represent no differentially expressed genes.