Research Paper Volume 13, Issue 14 pp 18018—18032

GAS6 ameliorates advanced age-associated meiotic defects in mouse oocytes by modulating mitochondrial function

GAS6 attenuates the decrease in the quality of aged oocytes. Aged oocytes showed increased mitochondrial deterioration, elevated oxidative stress and insufficient cytoplasmic maturation due to decreased Gas6 expression, resulting in meiotic defects and consequential PN formation failure. Moreover, GAS6-rescued aged oocytes collectively exhibited metabolic alterations, indicating better-quality mitochondrial functions. Therefore, the age-associated decreases in oocyte quality and fertility were prevented by restoring GAS6 levels.

Figure 5. GAS6 attenuates the decrease in the quality of aged oocytes. Aged oocytes showed increased mitochondrial deterioration, elevated oxidative stress and insufficient cytoplasmic maturation due to decreased Gas6 expression, resulting in meiotic defects and consequential PN formation failure. Moreover, GAS6-rescued aged oocytes collectively exhibited metabolic alterations, indicating better-quality mitochondrial functions. Therefore, the age-associated decreases in oocyte quality and fertility were prevented by restoring GAS6 levels.