Research Paper Advance Articles

Myeloid DJ-1 deficiency protects acetaminophen-induced acute liver injury through decreasing inflammatory response

Ablation of DJ-1 protects APAP-induced acute liver injury and mortality in mice. Fasted WT and DJ-1−/− mice were intraperitoneal injected with a single dose 300 mg/kg of APAP. Serum levels of ALT (A) and AST (B) were shown at the indicated time points after APAP injection (n = 4–6). (C) Representative images of HE staining of liver tissues of WT and DJ−/− mice at the indicated time points after APAP intraperitoneal injection (origin magnification ×100). (D) Survival rate of WT and DJ-1−/− mice after APAP (500 mg/kg) administration (n = 10 in each group). Data are shown as means ± SD, *P

Figure 1. Ablation of DJ-1 protects APAP-induced acute liver injury and mortality in mice. Fasted WT and DJ-1−/− mice were intraperitoneal injected with a single dose 300 mg/kg of APAP. Serum levels of ALT (A) and AST (B) were shown at the indicated time points after APAP injection (n = 4–6). (C) Representative images of HE staining of liver tissues of WT and DJ−/− mice at the indicated time points after APAP intraperitoneal injection (origin magnification ×100). (D) Survival rate of WT and DJ-1−/− mice after APAP (500 mg/kg) administration (n = 10 in each group). Data are shown as means ± SD, *P < 0.05.