Research Paper Advance Articles

Myeloid DJ-1 deficiency protects acetaminophen-induced acute liver injury through decreasing inflammatory response

DJ-1 deficiency attenuates the inflammatory response to APAP overdose. Fasted WT and DJ-1−/− mice were intraperitoneal injected with a single dose of 300 mg/kg of APAP. Serum TNF-α (A) and IL-6 (B) levels after APAP injection were measured by ELISA (n = 4–6). (C) Immunohistochemistry staining of hepatic F4/80 after APAP treatment. Representative images are shown (origin magnification ×100) (n = 4–6). (D) Immunohistochemistry of hepatic MPO after APAP treatment. Representative images are shown (origin magnification ×100) (n = 4–6). Data are shown as means ± SD, *P **P

Figure 2. DJ-1 deficiency attenuates the inflammatory response to APAP overdose. Fasted WT and DJ-1−/− mice were intraperitoneal injected with a single dose of 300 mg/kg of APAP. Serum TNF-α (A) and IL-6 (B) levels after APAP injection were measured by ELISA (n = 4–6). (C) Immunohistochemistry staining of hepatic F4/80 after APAP treatment. Representative images are shown (origin magnification ×100) (n = 4–6). (D) Immunohistochemistry of hepatic MPO after APAP treatment. Representative images are shown (origin magnification ×100) (n = 4–6). Data are shown as means ± SD, *P < 0.05; **P < 0.01.