Research Paper Volume 13, Issue 15 pp 19415—19441

Development and validation of an intra-tumor heterogeneity-related signature to predict prognosis of bladder cancer: a study based on single-cell RNA-seq

HRS was a potential predictor for clinical treatment of BCa. (A, B) HRS was significantly correlated with MATH, codetermined by difference (A) and correlation (B) analysis. (C) GAL-9 was differentially expressed between low- and high-HRS groups. (D) The cases in the high-HRS group were more likely to be associated with the high infiltration of M0 macrophages, activated mast cells, and neutrophils, whereas they were negatively correlated with the infiltration of CD8+ T cells and Tregs. (E) High HRS was linked to a lower IC50 for chemotherapeutics like cisplatin and doxorubicin, whereas it was correlated to a higher IC50 of methotrexate. *p **p ***p

Figure 7. HRS was a potential predictor for clinical treatment of BCa. (A, B) HRS was significantly correlated with MATH, codetermined by difference (A) and correlation (B) analysis. (C) GAL-9 was differentially expressed between low- and high-HRS groups. (D) The cases in the high-HRS group were more likely to be associated with the high infiltration of M0 macrophages, activated mast cells, and neutrophils, whereas they were negatively correlated with the infiltration of CD8+ T cells and Tregs. (E) High HRS was linked to a lower IC50 for chemotherapeutics like cisplatin and doxorubicin, whereas it was correlated to a higher IC50 of methotrexate. *p < 0.05; **p < 0.01; ***p < 0.001.