Research Paper Volume 13, Issue 15 pp 19415—19441

Development and validation of an intra-tumor heterogeneity-related signature to predict prognosis of bladder cancer: a study based on single-cell RNA-seq

Functional enrichment analysis. (A) The heatmap showing the analysis results of GSVA. (B, C) Four pathways, including G2M checkpoint, mitotic spindle, mTORC1 signaling, and epithelial mesenchymal transition, were positively related to HRS, which was codetermined by GSEA and GSVA. (D, E) Two pathways, including DNA repair and oxidative phosphorylation, were negatively associated with HRS through the combined analysis by GSEA and GSVA.

Figure 8. Functional enrichment analysis. (A) The heatmap showing the analysis results of GSVA. (B, C) Four pathways, including G2M checkpoint, mitotic spindle, mTORC1 signaling, and epithelial mesenchymal transition, were positively related to HRS, which was codetermined by GSEA and GSVA. (D, E) Two pathways, including DNA repair and oxidative phosphorylation, were negatively associated with HRS through the combined analysis by GSEA and GSVA.