Research Paper Volume 13, Issue 14 pp 19048—19063

Combined treatment with C16 peptide and angiopoietin-1 confers neuroprotection and reduces inflammation in 3-nitropropionic acid-induced dystonia mice

Significantly elevated pDARPP-32 expression was noted in the 3-NP group, but C16+Ang-1 treatment reduced pDARPP-32 expression. The PPE and Pdyn expression levels are indicators of imbalances between the striatopallidal and striatonigral pathways. 3-NP insult can increase Pdyn but decrease PPE in the striatum of mice in the 3-NP group. C16+Ang-1 treatment decreased Pdyn but increased PPE expression, suggesting that its mechanism of action likely involved protecting the indirect basal ganglia pathway and the PPE medium spiny neuronal terminals. Western blot images of the levels of (A, B) DARPP-32, (C, D) pDARPP-32, (E, F) Pdyn, and (G, H) PPE in the control, 3-NP, and 3-NP+C16+Ang-1 groups. aP bP

Figure 12. Significantly elevated pDARPP-32 expression was noted in the 3-NP group, but C16+Ang-1 treatment reduced pDARPP-32 expression. The PPE and Pdyn expression levels are indicators of imbalances between the striatopallidal and striatonigral pathways. 3-NP insult can increase Pdyn but decrease PPE in the striatum of mice in the 3-NP group. C16+Ang-1 treatment decreased Pdyn but increased PPE expression, suggesting that its mechanism of action likely involved protecting the indirect basal ganglia pathway and the PPE medium spiny neuronal terminals. Western blot images of the levels of (A, B) DARPP-32, (C, D) pDARPP-32, (E, F) Pdyn, and (G, H) PPE in the control, 3-NP, and 3-NP+C16+Ang-1 groups. aP < 0.05 versus control; bP < 0.05 versus 3-NP-treated mice.