Research Paper Volume 13, Issue 14 pp 19048—19063

Combined treatment with C16 peptide and angiopoietin-1 confers neuroprotection and reduces inflammation in 3-nitropropionic acid-induced dystonia mice

ELISA analysis of inflammatory cytokines (A) IL-6 and (B) ROS, as well as the inhibitory neurotransmitter. (A, B) The 3-NP+C16+Ang-1 group showed decreased IL-6 and ROS levels, suggesting that C16+Ang-1 could prevent 3-NP-induced inflammation. (C) GABA levels in serum samples of the control, 3-NP, and 3-NP+C16+Ang-1 groups. Suppression of inflammatory factors and increased GABA level could protect neurons that have been damaged by oxidative stress and excitatory toxin. aP bP

Figure 3. ELISA analysis of inflammatory cytokines (A) IL-6 and (B) ROS, as well as the inhibitory neurotransmitter. (A, B) The 3-NP+C16+Ang-1 group showed decreased IL-6 and ROS levels, suggesting that C16+Ang-1 could prevent 3-NP-induced inflammation. (C) GABA levels in serum samples of the control, 3-NP, and 3-NP+C16+Ang-1 groups. Suppression of inflammatory factors and increased GABA level could protect neurons that have been damaged by oxidative stress and excitatory toxin. aP < 0.05 versus control; bP < 0.05 versus 3-NP-treated mice.