Research Paper Volume 13, Issue 15 pp 19510—19528

UHPLC-MS-based metabolomics and chemoinformatics study reveals the neuroprotective effect and chemical characteristic in Parkinson’s disease mice after oral administration of Wen-Shen-Yang-Gan decoction

Effects of WSYGD on behavioral test of PD chronic model mice. In the pole test, (A) refers to the turning time and (B) refers to the total time; (C) refers to the retention time in the rotarod test. Control: blank group; Model: rotenone-intoxicated group; WSYGD-H: high dosage group; WSYGD-M: medium dosage group; WSYGD-L: Low dosage group; Sinemet: positive control. ***p

Figure 2. Effects of WSYGD on behavioral test of PD chronic model mice. In the pole test, (A) refers to the turning time and (B) refers to the total time; (C) refers to the retention time in the rotarod test. Control: blank group; Model: rotenone-intoxicated group; WSYGD-H: high dosage group; WSYGD-M: medium dosage group; WSYGD-L: Low dosage group; Sinemet: positive control. ***p<0.001 vs. Control; #p<0.05,##p<0.01, ###p<0.001 vs. Model.