Research Paper Volume 13, Issue 15 pp 19510—19528

UHPLC-MS-based metabolomics and chemoinformatics study reveals the neuroprotective effect and chemical characteristic in Parkinson’s disease mice after oral administration of Wen-Shen-Yang-Gan decoction

Changes of serum inflammatory factors including IL-10, IL-17, IL-22, IL-10, TGF-β1, TNF-α, IGF-1, IL-1β and NF-κB in Mice. Control: blank group; Model: rotenone-intoxicated group; WSYGD-H: high dosage group; WSYGD-M: medium dosage group; WSYGD-L: Low dosage group; Sinemet: positive control. **p

Figure 4. Changes of serum inflammatory factors including IL-10, IL-17, IL-22, IL-10, TGF-β1, TNF-α, IGF-1, IL-1β and NF-κB in Mice. Control: blank group; Model: rotenone-intoxicated group; WSYGD-H: high dosage group; WSYGD-M: medium dosage group; WSYGD-L: Low dosage group; Sinemet: positive control. **p<0.001, ***p<0.001 vs control; #p<0.05, ##p<0.01, ###p<0.001 vs Model.