Figure 2. Comparisons of emotional changes and brain reactivity to emotional stimuli among PMDD vs. control study participants (PMDD=23, controls=23) of the anger-induced group. (A–D) Extraversion, psychoticism, neuroticism, and social desirability T-scores. (E) Schematic presentation of the study participants in the experiment. (F) TAS-20 scores for both groups. (G–I) Anger emotions in the anger-induced group. (J) Illustration of activations in various brain areas. Compared to the HC group, the PMDD group exhibited increased activation, mainly in the middle frontal gyrus (BA10), temporal lobe (BA42), main part of left cerebellum (BA37), as well as decreased activation in the precuneus (BA7), superior frontal gyrus (BA8), paracentral lobule (BA6), and right cerebellum (BA48). (K) PMDD group and HC group Anger mood Subtract Neutral Frontal Mid-Back Picture Condition T-test activation Differential area; p < 0.05, cluster size > 389 warm (T value positive) represents PMDD group higher than the HC group, cool (T negative) on behalf of the normal group than the patient group.