Figure 7. Effect of Grape skin extract (GSE) on gene expression of (A) tumor necrosis factor-α (TNF-α) and (B) interleukin-6 (IL-6) and protein levels of TNF-α and IL-6 in the cerebral cortex (C, D) and the hippocampus (E, F) of SAMP8. SAMP8 mice were orally administered with 50 mg/kg GSE for 30 days. The gene expression of TNF-α and IL-6 were evaluated using real-time RT-PCR. And protein levels of TNF-α and IL-6 were determined by ELISA kit. Each value is presented as mean ± SD. ** P < 0.01 compared to SAMP8+Water by one-way ANOVA.