Research Paper Volume 13, Issue 15 pp 19643—19656

The protective effect of allicin on myocardial ischemia-reperfusion by inhibition of Ca2+ overload-induced cardiomyocyte apoptosis via the PI3K/GRK2/PLC-γ/IP3R signaling pathway

Allicin increased p-PI3K protein expression. (A) Immunofluorescence staining revealed that allicin could increase the level of p-PI3K in cardiomyocytes. (B) The quantitative analysis and western blot analysis revealed that allicin treatment caused a marked increase in the phosphorylation of Akt and PI3K compared with the MI/R group. (P

Figure 4. Allicin increased p-PI3K protein expression. (A) Immunofluorescence staining revealed that allicin could increase the level of p-PI3K in cardiomyocytes. (B) The quantitative analysis and western blot analysis revealed that allicin treatment caused a marked increase in the phosphorylation of Akt and PI3K compared with the MI/R group. (P < 0.05, Model vs. Allicin).