Research Paper Volume 13, Issue 17 pp 21134—21141

RNA N6-methyladenosine demethylase FTO promotes osteoporosis through demethylating Runx2 mRNA and inhibiting osteogenic differentiation

Inhibition of FTO promotes bone formation of OVX mice in vivo. (A) Representative images of μCT reconstructive images of tibial plateau in OVX groups with or without FTO inhibitor. (B) 3D structural parameters-BMD, BV/TV, Tb.N, Tb.Sp, Tb.Th and SMI-of tibial plateau by μCT in in OVX groups with or without FTO inhibitor. *PC) Representative hematoxylin-eosin staining images of tibial plateau showing bone volume in each group.

Figure 4. Inhibition of FTO promotes bone formation of OVX mice in vivo. (A) Representative images of μCT reconstructive images of tibial plateau in OVX groups with or without FTO inhibitor. (B) 3D structural parameters-BMD, BV/TV, Tb.N, Tb.Sp, Tb.Th and SMI-of tibial plateau by μCT in in OVX groups with or without FTO inhibitor. *P<0.05. (C) Representative hematoxylin-eosin staining images of tibial plateau showing bone volume in each group.