Figure 1. Differentially expressed circRNA profiles in OPLL. (A) Of all the 146 identified circRNAs, 28 of them were confirmed as novel circRNAs; 118 of them were previously reported in the database of circBase. (B) The 146 dysregulated circRNAs were classified into four different groups based on their origins. (C) The heatmap shows the top 15 upregulated and top 10 downregulated circRNAs between three OPLL and three non-OPLL tissue samples. (D, E) The expression of top 10 upregulated and top 4 downregulated circRNAs was measured by qRT-PCR (n=10). Data are expressed as the mean ± SD. ***p < 0.001; **p < 0.01.