Research Paper Volume 13, Issue 15 pp 19127—19144

The life in a gradient: calcium, the lncRNA SPRR2C and mir542/mir196a meet in the epidermis to regulate the aging process

The interaction between lncRNA SPRR2C and several miRNAs. In (A) the SPRR2C-miRNA hybrids are shown. The SPRR2C region is presented in red, the appropriate miRNA in green. Both RNA-miRNA hybrids and mfe were calculated using RNAhybrid (<a href="https://bibiserv.cebitec.uni-bielefeld.de/rnahybrid" target="

Figure 2. The interaction between lncRNA SPRR2C and several miRNAs. In (A) the SPRR2C-miRNA hybrids are shown. The SPRR2C region is presented in red, the appropriate miRNA in green. Both RNA-miRNA hybrids and mfe were calculated using RNAhybrid (https://bibiserv.cebitec.uni-bielefeld.de/rnahybrid). In (B) the SPRR2C mRNA is presented and the binding sites for hsa-mir542-5p, hsa-mir125a, hsa-mir135a-5p, hsa-mir196a-5p, hsa-mir491-5p and hsa-mir552-5p are marked. hsa-mir542-5p: red letters; hsa-mir125a-5p: yellow letters; hsa-mir135a-5p: red bracket; hsa-mir196a-5p: blue bracket; hsa-mir491-5p: green letters; hsa-mir552-5p: lower case letters.