Research Paper Volume 13, Issue 15 pp 19750—19759

Dual inhibition of FGFR4 and BCL-xL inhibits multi-resistant ovarian cancer with BCL2L1 gain


Figure 1. BCL2L1 is frequently gained in OvCa. Reproduced from TCGA OvCa dataset, shown were (A) copy number alteration of Cytoband 20q11.21 that encompassed BCL2L1; (B) frequency of gain (pink) and amplification (red) of BCL2L1 across all cancers in TCGA dataset; (C) differential expression of BCL2L1 across TCGA cancers; (D) Reproduced from CPTAC dataset, shown were protein level of BCL2L1 in different clinicopathological parameters; (E) representative IHC images of BCL2L1 in normal ovary tissue and ovarian cancer tissue; (F) overall and progression-free survival of OvCa cases with or without BCL2L1 gain/amplification in TCGA cohort; (G) overall survival of OvCa cases with top 30% or bottom 30% of BCL2L1 expression in TCGA cohort (*P < .05; **P < .01; ***P < .001; ****P < .0001).