Research Paper Volume 13, Issue 17 pp 21142—21154

Serglycin promotes proliferation, migration, and invasion via the JAK/STAT signaling pathway in osteosarcoma

SRGN affects the JAK/STAT signaling pathway in 143B cells. Western blot analysis of the expression of Bcl-2, JAK2, p-JAK2, STAT3, p-STAT3, and ACTIN. pcDNA3.1, means MOCK transfection with pcDNA3.1, and it was used as the empty control of the overexpression group; NC, negative control used as the control for siRNA experiments; * We set the quantized value of pcDNA3.1 and NC to 1.00. The other quantized values were compared with their respective experimental groups.

Figure 8. SRGN affects the JAK/STAT signaling pathway in 143B cells. Western blot analysis of the expression of Bcl-2, JAK2, p-JAK2, STAT3, p-STAT3, and ACTIN. pcDNA3.1, means MOCK transfection with pcDNA3.1, and it was used as the empty control of the overexpression group; NC, negative control used as the control for siRNA experiments; * We set the quantized value of pcDNA3.1 and NC to 1.00. The other quantized values were compared with their respective experimental groups.