Research Paper Volume 13, Issue 15 pp 19822—19834

Circular RNA ZNF609 drives tumor progression by regulating the miR-138-5p/SIRT7 axis in melanoma

CircZNF609 promotes proliferation and attenuates apoptosis of melanoma cells. (A–F) The A375 and SK-MEL-28 cells were treated with the circZNF609 shRNA or control shRNA. (A and B) The cell viability was tested by the MTT assays in the cells. (C and D) The cell proliferation was measured by colony formation assays in the cells. (E and F) The cell apoptosis was analyzed by flow cytometry analysis in the cells. Data are presented as mean ± SD. Statistic significant differences were indicated: *P **P ***P

Figure 1. CircZNF609 promotes proliferation and attenuates apoptosis of melanoma cells. (AF) The A375 and SK-MEL-28 cells were treated with the circZNF609 shRNA or control shRNA. (A and B) The cell viability was tested by the MTT assays in the cells. (C and D) The cell proliferation was measured by colony formation assays in the cells. (E and F) The cell apoptosis was analyzed by flow cytometry analysis in the cells. Data are presented as mean ± SD. Statistic significant differences were indicated: *P < 0.05, **P < 0.01, ***P < 0.001.