Research Paper Volume 13, Issue 15 pp 19165—19185

Endothelium-specific deletion of amyloid-β precursor protein exacerbates endothelial dysfunction induced by aging

Quantitative HPLC analysis of superoxide anion in aortas from young and aged wild-type (WT) littermates and eAPP−/− mice aortas. All results were normalized against tissue protein levels and are representing box plots with whiskers showing the median, 25th to 75th percentiles, and min-max range (n=8 per group for young WT littermates and eAPP−/− mice and n=10 per group for aged WT littermates and eAPP−/− mice). * P

Figure 7. Quantitative HPLC analysis of superoxide anion in aortas from young and aged wild-type (WT) littermates and eAPP−/− mice aortas. All results were normalized against tissue protein levels and are representing box plots with whiskers showing the median, 25th to 75th percentiles, and min-max range (n=8 per group for young WT littermates and eAPP−/− mice and n=10 per group for aged WT littermates and eAPP−/− mice). * P<0.05 versus young mice of same strain; † P<0.05 versus age-matched WT littermates (two-way ANOVA followed by Tukey’s HSD test).