Research Paper Volume 13, Issue 16 pp 20258—20276

DNMT3B decreases extracellular matrix degradation and alleviates intervertebral disc degeneration through TRPA1 methylation to inhibit the COX2/YAP axis

Diagram illustrating the pathway of our proposed hypothetical mechanism. DNMT3B reduces the levels of MMP3 and MMP9 and increases the levels of collagen II and aggrecan through the TRPA1-COX2-YAP axis. DNMT3B then reduces the ECM degradation of NP cells and the inflammatory response, thereby alleviating IVDD.

Figure 9. Diagram illustrating the pathway of our proposed hypothetical mechanism. DNMT3B reduces the levels of MMP3 and MMP9 and increases the levels of collagen II and aggrecan through the TRPA1-COX2-YAP axis. DNMT3B then reduces the ECM degradation of NP cells and the inflammatory response, thereby alleviating IVDD.