Research Paper Volume 13, Issue 16 pp 20302—20318

Regulation of follistatin-like 3 expression by miR-486-5p modulates gastric cancer cell proliferation, migration and tumor progression

Differential gene expression and functional enrichment during FSTL3 overexpression. (A) Volcano map of differentially expressed genes under conditions of elevated FSTL3 levels; adjusted PB) The top 10 differentially expressed genes (linked to FSTL3 overexpression) in gastric cancer disease presented as a gene expression heat map. (C) Gene ontology (GO) term enrichment analysis; adjusted PD) Kyoto Encyclopedia of Genes and Genomes (KEGG) biochemical pathway enrichment analysis; adjusted PE) Protein-protein interaction (PPI) network analysis for 122 differentially expressed genes linked to gastric cancer; minimum required interaction score: 0.900. (F) Specific PPI nodes within the full network with MYOCD tool in Cytoscape.

Figure 2. Differential gene expression and functional enrichment during FSTL3 overexpression. (A) Volcano map of differentially expressed genes under conditions of elevated FSTL3 levels; adjusted P<0.05. (B) The top 10 differentially expressed genes (linked to FSTL3 overexpression) in gastric cancer disease presented as a gene expression heat map. (C) Gene ontology (GO) term enrichment analysis; adjusted P<0.05. (D) Kyoto Encyclopedia of Genes and Genomes (KEGG) biochemical pathway enrichment analysis; adjusted P<0.05. (E) Protein-protein interaction (PPI) network analysis for 122 differentially expressed genes linked to gastric cancer; minimum required interaction score: 0.900. (F) Specific PPI nodes within the full network with MYOCD tool in Cytoscape.