Research Paper Volume 13, Issue 16 pp 20335—20358

Proteomic characterization of secretory granules in dopaminergic neurons indicates chromogranin/secretogranin-mediated protein processing impairment in Parkinson’s disease

Enrichment and PPI analysis of 56 significantly differentially expressed proteins on the secretory granules. (A) The involved biological processes (BP) of the 56 secretory granule proteins in Gene Ontology (GO) analysis. (B) The dysregulated BP indicated by GO analysis. (C) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of the 56 secretory granules proteins. (D) protein-protein interactions (PPI) network of 56 SGs proteins constructed by the Search Tool for the Retrieval of Interacting Genes (STRING) database. (E) Clustering analysis was conducted by molecular complex detection (MCODE) of Cytoscape software.

Figure 6. Enrichment and PPI analysis of 56 significantly differentially expressed proteins on the secretory granules. (A) The involved biological processes (BP) of the 56 secretory granule proteins in Gene Ontology (GO) analysis. (B) The dysregulated BP indicated by GO analysis. (C) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of the 56 secretory granules proteins. (D) protein-protein interactions (PPI) network of 56 SGs proteins constructed by the Search Tool for the Retrieval of Interacting Genes (STRING) database. (E) Clustering analysis was conducted by molecular complex detection (MCODE) of Cytoscape software.