Research Paper Volume 13, Issue 16 pp 20372—20382

Circular RNA circRHOT1 contributes to pathogenesis of non-small cell lung cancer by epigenetically enhancing C-MYC expression through recruiting KAT5

The depletion of circRHOT1 induces NSCLC cell apoptosis and cell cycle arrest in vitro. (A–D) The A549 and H1299 cells were treated with control siRNA or circRHOT1 siRNA. (A and B) The cell apoptosis was measure by flow cytometry analysis. (C and D) The cell cycle was analyzed by flow cytometry analysis. mean ± SD, **P

Figure 3. The depletion of circRHOT1 induces NSCLC cell apoptosis and cell cycle arrest in vitro. (AD) The A549 and H1299 cells were treated with control siRNA or circRHOT1 siRNA. (A and B) The cell apoptosis was measure by flow cytometry analysis. (C and D) The cell cycle was analyzed by flow cytometry analysis. mean ± SD, **P < 0.01.