Research Paper Volume 13, Issue 16 pp 19978—19995

TGF-β2 and collagen play pivotal roles in the spheroid formation and anti-aging of human dermal papilla cells

A proposed scheme for the involvement of TGF-β2 and collagen in the aggregative behavior and anti-aging of hDPCs. COL13A1 and COL15A1 upregulation by TGF-β2 increases the spheroidal formation of DPCs, thereby reducing cellular senescence and inducing the hair inductivity of DPCs.

Figure 7. A proposed scheme for the involvement of TGF-β2 and collagen in the aggregative behavior and anti-aging of hDPCs. COL13A1 and COL15A1 upregulation by TGF-β2 increases the spheroidal formation of DPCs, thereby reducing cellular senescence and inducing the hair inductivity of DPCs.