**Figure 1.** High expression of UPF1 in EEC: (**A**, **B**) 28 (66.7%) of 42 EEC patients had high expression of UPF1. In 5 of 42 cases (11.9%), the expression level was lower than normal tissues. Of the 42 cases, 9 had no significant difference with normal tissues. (**C**) Overall analysis the high expression of UPF1 in EEC is of great significance. (**D**) Immunohistochemical results showed that the positive rate of 17 (80.95%) of the 21 patients (T) was higher than that of the normal control group (N). The positive rate of 4 cases (T) (19.05%) was lower than that of the normal control group (N)(NIKON, 200X). (**E**) Scoring of immunohistochemistry. Data was represented as the mean +/- SEM.*P<0.05, **P<0.01, ***P<0.001.