Figure 6. UPF1 influenced tumor growth, mTOR signal pathway and autophagy in vivo. (A, G) Photographs showing tumors that Lentivirus transfected with UPF1 stable expressed Ishikawa cell line (LV-UPF1+) and the control (LV-CON238), and that Lentivirus transfected with interfered UPF1 expressed Ishikawa cell line(LV-UPF1-RNAi), the control (LV-CON077) and wild Type group (WT). (B, H) qRT-PCR detected the relative expression of UPF1 in stable cell line. (C, I) The means tumor weights in nude mice were significant compared with the control group (**P<0.01). (D, J) H&E-stained slides (NIKON,400X) and IHC showed expression of UPF1 in tumors. (E, F, K, L) The mTOR related proteins’ and autophagy related proteins’ expression in tumors.