Research Paper Volume 13, Issue 15 pp 19207—19229

Hedgehog dysregulation contributes to tissue-specific inflammaging of resident macrophages

Sex-specific physiological aging generates altered endotoxin responses in tissue-resident macrophages. Venn diagrams show the numbers of LPS-regulated genes common and unique to young and old macrophages. Each set of LPS-induced or -repressed genes was defined as those differentially expressed between macrophages untreated and treated with LPS (10ng/ml) for 3 hours. The names of top genes based on 3h fold change +/- LPS are shown next to each Venn diagram. The areas of Venn diagram regions are proportional to the size of the represented subsets.

Figure 3. Sex-specific physiological aging generates altered endotoxin responses in tissue-resident macrophages. Venn diagrams show the numbers of LPS-regulated genes common and unique to young and old macrophages. Each set of LPS-induced or -repressed genes was defined as those differentially expressed between macrophages untreated and treated with LPS (10ng/ml) for 3 hours. The names of top genes based on 3h fold change +/- LPS are shown next to each Venn diagram. The areas of Venn diagram regions are proportional to the size of the represented subsets.