Figure 4. Gene expression profiles were significantly altered in HCC cells that overexpressed WISP2. (A) Heatmap shows the gene expression profiles of Hep3B cells with and without overexpression of WISP2. (B) The differentially expressed genes were evaluated using Gene Ontology analysis. (C) The differentially expressed genes were evaluated by KEGG pathway analysis. (D) Differentially expressed genes were found to be involved in wounding healing (a), anti-apoptosis (b), cell cycle (c), and drug resistance (d).