Research Paper Volume 13, Issue 17 pp 21216—21231

Dual roles of WISP2 in the progression of hepatocellular carcinoma: implications of the fibroblast infiltration into the tumor microenvironment

Gene expression profiles were significantly altered in HCC cells that overexpressed WISP2. (A) Heatmap shows the gene expression profiles of Hep3B cells with and without overexpression of WISP2. (B) The differentially expressed genes were evaluated using Gene Ontology analysis. (C) The differentially expressed genes were evaluated by KEGG pathway analysis. (D) Differentially expressed genes were found to be involved in wounding healing (a), anti-apoptosis (b), cell cycle (c), and drug resistance (d).

Figure 4. Gene expression profiles were significantly altered in HCC cells that overexpressed WISP2. (A) Heatmap shows the gene expression profiles of Hep3B cells with and without overexpression of WISP2. (B) The differentially expressed genes were evaluated using Gene Ontology analysis. (C) The differentially expressed genes were evaluated by KEGG pathway analysis. (D) Differentially expressed genes were found to be involved in wounding healing (a), anti-apoptosis (b), cell cycle (c), and drug resistance (d).