Research Paper Volume 13, Issue 16 pp 20495—20510

Anti-apoptotic and pro-survival effect of exercise training on early aged hypertensive rat cerebral cortex

Proposed hypothesis indicating that early aged hypertension appear to activate the EndoG/AIF-related caspase-independent, Fas/FasL-mediated caspase-dependent apoptotic pathways (Fas ligand, Fas receptor, TNF-α, TNF receptor 1, Fas-associated death domain, active Caspase-8 and active Caspase-3) and mitochondria-mediated caspase-dependent apoptotic pathway (t-Bid, Bax, Bak, Bad, cytochrome c, Apaf-1, active Caspase 9 and active Caspase-3) as well as suppresses Bcl-2 family-related pro-survival pathway (Bcl2, Bcl-xL, p-Bad, 14-3-3) and IGF-1 related pro-survival pathway (IGF-1, pPI3K/PI3K, and pAKT/AKT). Whereas, exercise training tends to inhibits early aged hypertension-induce neural EndoG/AIF related caspase-independent, hypertension-induce Fas/FasL-mediated apoptotic and hypertension-induce mitochondria-mediated caspase-dependent apoptotic pathway as well as enhances Bcl-2 family-related pro-survival and IGF-1-related pro-survival pathway.

Figure 7. Proposed hypothesis indicating that early aged hypertension appear to activate the EndoG/AIF-related caspase-independent, Fas/FasL-mediated caspase-dependent apoptotic pathways (Fas ligand, Fas receptor, TNF-α, TNF receptor 1, Fas-associated death domain, active Caspase-8 and active Caspase-3) and mitochondria-mediated caspase-dependent apoptotic pathway (t-Bid, Bax, Bak, Bad, cytochrome c, Apaf-1, active Caspase 9 and active Caspase-3) as well as suppresses Bcl-2 family-related pro-survival pathway (Bcl2, Bcl-xL, p-Bad, 14-3-3) and IGF-1 related pro-survival pathway (IGF-1, pPI3K/PI3K, and pAKT/AKT). Whereas, exercise training tends to inhibits early aged hypertension-induce neural EndoG/AIF related caspase-independent, hypertension-induce Fas/FasL-mediated apoptotic and hypertension-induce mitochondria-mediated caspase-dependent apoptotic pathway as well as enhances Bcl-2 family-related pro-survival and IGF-1-related pro-survival pathway.