Research Paper Volume 13, Issue 16 pp 19996—20015

Stress-induced aberrations in sensory processing predict worse cognitive outcomes in healthy aging adults

Life and biological stress in healthy aging adults. (Left) Violin/box plots of allostatic load score (Mean ± SD: 2.7 E -5 ± 0.85) extracted from the exploratory factor analysis of depression symptom severity, BMI, perceived declines in ADL, and total years of education with positive values indicative of elevated levels of life stress in our sample. (Right) Violin/box plots of relative age advancement (Mean ± SD: -0.18 ± 5.08), which was computed using the residuals from a regression of the consensus DNA methylation model of predicted biological age on chronological age in our sample.

Figure 4. Life and biological stress in healthy aging adults. (Left) Violin/box plots of allostatic load score (Mean ± SD: 2.7 E -5 ± 0.85) extracted from the exploratory factor analysis of depression symptom severity, BMI, perceived declines in ADL, and total years of education with positive values indicative of elevated levels of life stress in our sample. (Right) Violin/box plots of relative age advancement (Mean ± SD: -0.18 ± 5.08), which was computed using the residuals from a regression of the consensus DNA methylation model of predicted biological age on chronological age in our sample.