Research Paper Volume 13, Issue 18 pp 22109—22119

LHX9, a p53-binding protein, inhibits the progression of glioma by suppressing glycolysis

LHX9 down-regulation accelerated the in vivo tumorigenicity of glioma cells. (A) Tumor growth curve. SK-N-SH cells were interfered with the expression of LHX9 or the expressions of both LHX9 and PGK1. The in-vivo tumor formation experiments were performed in nude mice and the tumor volume was recorded. (B, C) Tumor morphology and tumor weight. (D) Expressions of LHX9 and PGK1 in tumors were detected by Western blot. ##, PP

Figure 6. LHX9 down-regulation accelerated the in vivo tumorigenicity of glioma cells. (A) Tumor growth curve. SK-N-SH cells were interfered with the expression of LHX9 or the expressions of both LHX9 and PGK1. The in-vivo tumor formation experiments were performed in nude mice and the tumor volume was recorded. (B, C) Tumor morphology and tumor weight. (D) Expressions of LHX9 and PGK1 in tumors were detected by Western blot. ##, P<0.01; **, P<0.01.