Research Paper Volume 13, Issue 16 pp 20552—20568

Mediation of circ_RPPH1 on miR-146b-3p/E2F2 pathway to hinder the growth and metastasis of breast carcinoma cells

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Figure 6. circ_RPPH1 can improve tumor growth in nude mice with BC. (A) Tumor growth in nude mice within 5 weeks. (B) After 5 weeks, the nude mice were executed and the tumor tissue was collected. (C) qRT-PCR was used to detect the relative expression of miR-146b-3p and E2F2 in tumor tissues of nude mice. (D) WB was used to detect the expression of E2F2 protein in tumor tissues of nude mice. (E) H&E staining of the lungs from mice. Scale bars, 50 μm. (F) qRT-PCR was used to detect the relative expression of circ_RPPH1 in tumor tissues of nude mice. *indicates P < 0.05; **indicates P < 0.01.