Research Paper Volume 13, Issue 17 pp 21232—21250

LncRNA SNHG17 promotes tumor progression and predicts poor survival in human renal cell carcinoma via sponging miR-328-3p

MiR-328-3p reverses SNHG17-induced tumor-promoting effects of RCC. (A–D) CCK-8 assay, CellTiter-Glo Luminescent cell viability assay, activity of caspase-3, 8, and 9 assay, wound healing and transwell assay were performed in ACHN cells transfected with siRNA scramble control (siSCR), siRNA against SNHG17 (siSNHG17) or H2AX (siH2AX), and miR-328-3p inhibitor or negative control inhibitor (NC inh) by special commercial kits. (E) Proposed model of the mechanism underlying the expression and function of SNHG17 in RCC cell. RCC, renal cell carcinoma. *P **P ***P

Figure 6. MiR-328-3p reverses SNHG17-induced tumor-promoting effects of RCC. (AD) CCK-8 assay, CellTiter-Glo Luminescent cell viability assay, activity of caspase-3, 8, and 9 assay, wound healing and transwell assay were performed in ACHN cells transfected with siRNA scramble control (siSCR), siRNA against SNHG17 (siSNHG17) or H2AX (siH2AX), and miR-328-3p inhibitor or negative control inhibitor (NC inh) by special commercial kits. (E) Proposed model of the mechanism underlying the expression and function of SNHG17 in RCC cell. RCC, renal cell carcinoma. *P < 0.05; **P < 0.01; ***P < 0.001.