Research Paper Volume 13, Issue 17 pp 21268—21282

Celecoxib reverses the glioblastoma chemo-resistance to temozolomide through mitochondrial metabolism

Cytostatic effects of celecoxib on GBM LN18 and LN229 cells assay by MTS. (A) LN18 cells (5×103) were seeded into 96-well plates, and the absorbance of the cells was detected at day1 to day5 in culture medium under various conditions, as indicated. (B) LN229 cells (5×103) were seeded into 96-well plates, and the absorbance of the cells was detected at day1 to day5 in culture medium under various conditions, as indicated. Data shows mean Absorbance 490nm and ±SEM, four independent wells per condition.

Figure 1. Cytostatic effects of celecoxib on GBM LN18 and LN229 cells assay by MTS. (A) LN18 cells (5×103) were seeded into 96-well plates, and the absorbance of the cells was detected at day1 to day5 in culture medium under various conditions, as indicated. (B) LN229 cells (5×103) were seeded into 96-well plates, and the absorbance of the cells was detected at day1 to day5 in culture medium under various conditions, as indicated. Data shows mean Absorbance 490nm and ±SEM, four independent wells per condition.