Research Paper Volume 13, Issue 16 pp 20609—20628

Intravascular emboli relates to immunosuppressive tumor microenvironment and predicts prognosis in stage III colorectal cancer

DEGs and hierarchical clustering analysis in the IVE group compared with the non-IVE group. (A) Volcano plot of DEGs between the IVE group and the non-IVE group. Genes significantly up-regulated are highlighted in red while down-regulated genes are highlighted in blue. The P-value threshold and cutoff of absolute fold change were 2, respectively. (B) Heat map clustering of gene expression in cancer tissue resected from six patients. Each column represents 1 individual patient tumor and each row represents 1 gene. Color indicate normalized counts of each gene, with red representing higher expression and green relatively lower expression.

Figure 4. DEGs and hierarchical clustering analysis in the IVE group compared with the non-IVE group. (A) Volcano plot of DEGs between the IVE group and the non-IVE group. Genes significantly up-regulated are highlighted in red while down-regulated genes are highlighted in blue. The P-value threshold and cutoff of absolute fold change were <0.05 and >2, respectively. (B) Heat map clustering of gene expression in cancer tissue resected from six patients. Each column represents 1 individual patient tumor and each row represents 1 gene. Color indicate normalized counts of each gene, with red representing higher expression and green relatively lower expression.