Research Paper Volume 13, Issue 16 pp 20684—20697

Construction of an immune-related lncRNA signature as a novel prognosis biomarker for LUAD

Validation of the 6-DEirlncRNA pair signature. (A, B) The modified LASSO penalized regression analysis identified eight DEirlncRNA pairs most related to prognostics. (C, D) The ROC showed the optimal cut-off point based on AIC value. (E) The 1-, 2-, 3-year AUC values were >0.7. (F) High-risk patients exhibited worse OS than the low-risk patients. (G, H) Univariate (G) and multivariate (H) Cox regression analysis of risk score, age, sex, and tumor-node-metastasis (TNM) stage indicating that risk score (HR = 1.467 [1.343–1.603], p p

Figure 3. Validation of the 6-DEirlncRNA pair signature. (A, B) The modified LASSO penalized regression analysis identified eight DEirlncRNA pairs most related to prognostics. (C, D) The ROC showed the optimal cut-off point based on AIC value. (E) The 1-, 2-, 3-year AUC values were >0.7. (F) High-risk patients exhibited worse OS than the low-risk patients. (G, H) Univariate (G) and multivariate (H) Cox regression analysis of risk score, age, sex, and tumor-node-metastasis (TNM) stage indicating that risk score (HR = 1.467 [1.343–1.603], p < 0.001) and stage (HR = 1.422, [CI] = [1.222–1.654], p < 0.001) were related to survival.