Research Paper Volume 13, Issue 17 pp 21309—21324

Activation of the gut microbiota-kynurenine-liver axis contributes to the development of nonalcoholic hepatic steatosis in nondiabetic adults

Fecal metabolomics analysis. (A) OPLS-DA score plots in positive ion mode. (B) OPLS-DA score plots in negative ion mode. (C) Differentially regulated metabolites in positive ion mode. (D) Differentially regulated metabolites in negative ion mode. (E–F) KEGG pathway analysis of differentially expressed metabolites in positive and negative ion modes. (G) Representative differential metabolites. Data are mean ± SE; h: control group; z: NHS group; *P

Figure 3. Fecal metabolomics analysis. (A) OPLS-DA score plots in positive ion mode. (B) OPLS-DA score plots in negative ion mode. (C) Differentially regulated metabolites in positive ion mode. (D) Differentially regulated metabolites in negative ion mode. (EF) KEGG pathway analysis of differentially expressed metabolites in positive and negative ion modes. (G) Representative differential metabolites. Data are mean ± SE; h: control group; z: NHS group; *P < 0.05.