Research Paper Volume 13, Issue 18 pp 22120—22133

Metformin inhibits hepatocellular carcinoma development by inducing apoptosis and pyroptosis through regulating FOXO3

Met inhibits the proliferation of HCC cells in a dose-dependent manner. An MTT assay was used to evaluate the proliferation of (A) Huh7, (B) SMMC-7721, (C) SMMC-LM3, (D) Hep3B, (E) Huh7, and (F) HNU-499 cells under different concentrations of Met (5, 10, 20 μM). *P

Figure 1. Met inhibits the proliferation of HCC cells in a dose-dependent manner. An MTT assay was used to evaluate the proliferation of (A) Huh7, (B) SMMC-7721, (C) SMMC-LM3, (D) Hep3B, (E) Huh7, and (F) HNU-499 cells under different concentrations of Met (5, 10, 20 μM). *P<0.05 vs. control group.