Research Paper Volume 13, Issue 18 pp 22120—22133

Metformin inhibits hepatocellular carcinoma development by inducing apoptosis and pyroptosis through regulating FOXO3


Figure 1. Met inhibits the proliferation of HCC cells in a dose-dependent manner. An MTT assay was used to evaluate the proliferation of (A) Huh7, (B) SMMC-7721, (C) SMMC-LM3, (D) Hep3B, (E) Huh7, and (F) HNU-499 cells under different concentrations of Met (5, 10, 20 μM). *P<0.05 vs. control group.