Research Paper Volume 13, Issue 18 pp 22120—22133

Metformin inhibits hepatocellular carcinoma development by inducing apoptosis and pyroptosis through regulating FOXO3

NLRP3 and IL-1β are downregulated in HCC tissues and cell lines. (A, D) qPCR was performed to evaluate NLRP3 and IL-1β expression in HCC tumor tissues and paracancerous tissues. (B, E) The expression data of NLRP3 and IL-1β in the starBase dataset. (C, F) Western blot was performed to evaluate the expression of NLRP3 and IL-1β in HCC cell lines. *P

Figure 7. NLRP3 and IL-1β are downregulated in HCC tissues and cell lines. (A, D) qPCR was performed to evaluate NLRP3 and IL-1β expression in HCC tumor tissues and paracancerous tissues. (B, E) The expression data of NLRP3 and IL-1β in the starBase dataset. (C, F) Western blot was performed to evaluate the expression of NLRP3 and IL-1β in HCC cell lines. *P<0.05 vs. normal or LO2 group. HCC, hepatocellular carcinoma.