Research Paper Volume 13, Issue 18 pp 22120—22133

Metformin inhibits hepatocellular carcinoma development by inducing apoptosis and pyroptosis through regulating FOXO3

Met inhibits HCC cell growth in vivo. (A) Image of tumors in each group. (B) Growth curves of the tumors in each group. (C) Tumor weights in the different groups. (D) IHC was used to evaluate the expression of Ki-67, NLRP3, caspase1, IL-1β, and IL-18. *P

Figure 8. Met inhibits HCC cell growth in vivo. (A) Image of tumors in each group. (B) Growth curves of the tumors in each group. (C) Tumor weights in the different groups. (D) IHC was used to evaluate the expression of Ki-67, NLRP3, caspase1, IL-1β, and IL-18. *P<0.05, Met vs. control group, Met + si-FOXO3 vs. Met+si-nc group.