Research Paper Volume 13, Issue 16 pp 20774—20792

NF-κB inducible miR-30b-5p aggravates joint pain and loss of articular cartilage via targeting SIRT1-FoxO3a-mediated NLRP3 inflammasome

miR-30b-5p expression was heightened in OA rat articular cartilage tissues and IL-1β-treated chondrocytes. DMM was induced to construct an SD rat model. (A) The miR-30b-5p profile in OA tissues was verified by RT-qPCR, N=5. IL-1β (5 ng/mL) was adopted to treat HC-A human chondrocytes. (B) RT-qPCR examined the miR-30b-5p profile in HC-A cells. *PPP

Figure 2. miR-30b-5p expression was heightened in OA rat articular cartilage tissues and IL-1β-treated chondrocytes. DMM was induced to construct an SD rat model. (A) The miR-30b-5p profile in OA tissues was verified by RT-qPCR, N=5. IL-1β (5 ng/mL) was adopted to treat HC-A human chondrocytes. (B) RT-qPCR examined the miR-30b-5p profile in HC-A cells. *P<0.05, **P<0.01, ***P<0.001, vs. con group. N=3.