Research Paper Volume 13, Issue 16 pp 19963—19977

The interplay between gray matter and white matter neurodegeneration in subjective cognitive decline

Association of subjective cognitive complaints and age with cortical thickness and white matter integrity. (A) Represents the cortical thinning exclusively associated with subjective cognitive complaints (pink), the cortical thinning exclusively associated with age (blue), and the cortical thinning associated with both complaints and age (orange). (B) Represents the increase in mean diffusivity exclusively associated with subjective cognitive complaints (pink), the increase in mean diffusivity exclusively associated with age (blue), and the increase in mean diffusivity associated with both complaints and age (orange); The white matter skeleton is represented in white color. All the represented clusters are statistically significant at p>0.01 after correction for multiple testing; A: anterior; P: posterior; S: superior; I: inferior; L: left; R: right; SCC: subjective cognitive complaints.

Figure 1. Association of subjective cognitive complaints and age with cortical thickness and white matter integrity. (A) Represents the cortical thinning exclusively associated with subjective cognitive complaints (pink), the cortical thinning exclusively associated with age (blue), and the cortical thinning associated with both complaints and age (orange). (B) Represents the increase in mean diffusivity exclusively associated with subjective cognitive complaints (pink), the increase in mean diffusivity exclusively associated with age (blue), and the increase in mean diffusivity associated with both complaints and age (orange); The white matter skeleton is represented in white color. All the represented clusters are statistically significant at p>0.01 after correction for multiple testing; A: anterior; P: posterior; S: superior; I: inferior; L: left; R: right; SCC: subjective cognitive complaints.