Research Paper Volume 13, Issue 17 pp 21364—21384

Deferoxamine accelerates endothelial progenitor cell senescence and compromises angiogenesis

DFO accelerates rat early EPC senescence in vivo. (A–C) Three-month-old Sprague-Dawley rats were intraperitoneally injected with the indicated dose (mg/kg/day) of DFO for four weeks. Early EPCs were harvested for assessments of colony formation, SA-βGal activity and ATP production. * P

Figure 6. DFO accelerates rat early EPC senescence in vivo. (AC) Three-month-old Sprague-Dawley rats were intraperitoneally injected with the indicated dose (mg/kg/day) of DFO for four weeks. Early EPCs were harvested for assessments of colony formation, SA-βGal activity and ATP production. * P < 0.05, ** P < 0.01 compared with the untreated group.