Research Paper Volume 13, Issue 17 pp 21364—21384

Deferoxamine accelerates endothelial progenitor cell senescence and compromises angiogenesis

FeCl3 but not antioxidant rescues the DFO-induced senescent phenotypes and proliferation inhibition. (A) SA-βGal activity assay of EPCs. EPCs were treated with FeCl3 or DFO (3 μM) plus FeCl3, N-acetylcysteine (NAC), and Resveratrol (Res) as indicated concentrations for 4 days. (B) Iron but not antioxidants rescued DFO-induced proliferation inhibition. EPCs were treated with FeCl3 or DFO plus FeCl3 and antioxidants as described in (A). ** Compared with vehicle, P

Figure 7. FeCl3 but not antioxidant rescues the DFO-induced senescent phenotypes and proliferation inhibition. (A) SA-βGal activity assay of EPCs. EPCs were treated with FeCl3 or DFO (3 μM) plus FeCl3, N-acetylcysteine (NAC), and Resveratrol (Res) as indicated concentrations for 4 days. (B) Iron but not antioxidants rescued DFO-induced proliferation inhibition. EPCs were treated with FeCl3 or DFO plus FeCl3 and antioxidants as described in (A). ** Compared with vehicle, P < 0.01.