Research Paper Volume 13, Issue 18 pp 22134—22147

Rutin inhibited the advanced glycation end products-stimulated inflammatory response and extra-cellular matrix degeneration via targeting TRAF-6 and BCL-2 proteins in mouse model of osteoarthritis

Effect of Rutin on AGE-induced ECM degradation in chondrocytes. (A) ELISA analysis for effect of Rutin treatment on levels of Collagen II, Aggrecan, ADAMTS-5 and MMP13. (B) Immunofluorescence along with DAPI staining analysis for detection of ADAMTS-5 and collagen II in chondrocytes. The results were mean ± SD. **P

Figure 3. Effect of Rutin on AGE-induced ECM degradation in chondrocytes. (A) ELISA analysis for effect of Rutin treatment on levels of Collagen II, Aggrecan, ADAMTS-5 and MMP13. (B) Immunofluorescence along with DAPI staining analysis for detection of ADAMTS-5 and collagen II in chondrocytes. The results were mean ± SD. **P<0.01 compared to control, ##P<0.01 compared to AGEs alone treated chondrocytes.