Research Paper Volume 13, Issue 18 pp 22134—22147

Rutin inhibited the advanced glycation end products-stimulated inflammatory response and extra-cellular matrix degeneration via targeting TRAF-6 and BCL-2 proteins in mouse model of osteoarthritis

Rutin inhibits AGE-induced MAPK pathway proteins in chondrocytes. (A) Western blot analysis showing protein expression of TRAF6 and p-JNK. (B) Quantitative results showing relative expression of TRAF6 and JNK. The results were mean ± SD. **P

Figure 5. Rutin inhibits AGE-induced MAPK pathway proteins in chondrocytes. (A) Western blot analysis showing protein expression of TRAF6 and p-JNK. (B) Quantitative results showing relative expression of TRAF6 and JNK. The results were mean ± SD. **P<0.01 compared to control group, ##P<0.01 compared to AGEs alone treated group.