Research Paper Volume 13, Issue 16 pp 20793—20807

Stimulator of interferon response cGAMP interactor overcomes ERBB2-mediated apatinib resistance in head and neck squamous cell carcinoma

Highly expressed VEGFR2(KDR) induces angiogenesis in HNSCC. (A, B) qRT-PCR and western blotting results for VEGFR2 in HIOEC and HNSCC cell lines (HN30, CAL27, and HN6) (C) Representative images of HN6 and HN30 subcutaneous tumors using immunofluorescence staining against CD31 and DAPI staining of nuclei. Higher angiogenesis was observed in the HN30 group, which has a higher VEGFR2 expression level. *P

Figure 1. Highly expressed VEGFR2(KDR) induces angiogenesis in HNSCC. (A, B) qRT-PCR and western blotting results for VEGFR2 in HIOEC and HNSCC cell lines (HN30, CAL27, and HN6) (C) Representative images of HN6 and HN30 subcutaneous tumors using immunofluorescence staining against CD31 and DAPI staining of nuclei. Higher angiogenesis was observed in the HN30 group, which has a higher VEGFR2 expression level. *P < 0.05, **P < 0.01, ***P < 0.001 versus the control.