Research Paper Volume 13, Issue 16 pp 20793—20807

Stimulator of interferon response cGAMP interactor overcomes ERBB2-mediated apatinib resistance in head and neck squamous cell carcinoma

The combination of vadimenzan and lapatinib re-sensitizes AR cells to apatinib in vivo. (A) After washing with PBS three times, AR cells (total of 1 × 106) suspended in 50 μL of DMEM were injected in each injection site. The tumor volumes of the mice were evaluated among the three groups. (B) Ki67 staining images of cancer samples in the different groups. (C) Representative images of subcutaneous tumors using immunofluorescence staining against CD31 and DAPI nuclear staining. *P

Figure 5. The combination of vadimenzan and lapatinib re-sensitizes AR cells to apatinib in vivo. (A) After washing with PBS three times, AR cells (total of 1 × 106) suspended in 50 μL of DMEM were injected in each injection site. The tumor volumes of the mice were evaluated among the three groups. (B) Ki67 staining images of cancer samples in the different groups. (C) Representative images of subcutaneous tumors using immunofluorescence staining against CD31 and DAPI nuclear staining. *P < 0.05, **P < 0.01, versus the control.